Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.

Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin.

Accidental exposure to ionizing radiation may lead to delayed effects of acute radiation exposure (DEARE) in many organ systems. Activated protein C (APC) is a known mitigator of the acute radiation syndrome. To examine the role of APC in DEARE, we used a transgenic mouse model with 2- to 3-fold inc...

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Bibliographic Details
Main Authors: Vijayalakshmi Sridharan, Kristin A Johnson, Reid D Landes, Maohua Cao, Preeti Singh, Gail Wagoner, Abdallah Hayar, Emily D Sprick, Kayla A Eveld, Anusha Bhattacharyya, Kimberly J Krager, Nukhet Aykin-Burns, Hartmut Weiler, Jose A Fernández, John H Griffin, Marjan Boerma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0252142

Internet

https://doi.org/10.1371/journal.pone.0252142

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