Homoharringtonine Combined with the Heat Shock Protein 90 Inhibitor IPI504 in the Treatment of FLT3-ITD Acute Myeloid Leukemia

Homoharringtonine Combined with the Heat Shock Protein 90 Inhibitor IPI504 in the Treatment of FLT3-ITD Acute Myeloid Leukemia

As a heterogeneous group of clonal disorders, acute myeloid leukemia with internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD) mutation usually shows an inferior prognosis. In the present study, we found that homoharringtonine (HHT), a protein translation inhibitor of plant alkaloid...

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Bibliographic Details
Main Authors: Zhaoxing Wu, Haifeng Zhuang, Qingfeng Yu, Xuzhao Zhang, Xudong Jiang, Xiaoya Lu, Ying Xu, Linlin Yang, Bowen Wu, An Ma, Lei Zhang, Xibin Xiao, Yun Liang, Ruilan Gao, Jianping Shen, Rongzhen Xu
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318305795

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http://www.sciencedirect.com/science/article/pii/S1936523318305795

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