Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+/K+-ATPase β2: potential molecular entities to treat invasive brain cancer

Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+/K+-ATPase β2: potential molecular entities to treat invasive brain cancer

Abstract Background Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal parenchyma, leading to the formation of recurrent tumors often adjacent to the surgical extraction site. We recently showed that Phoneutria nigriventer spider venom (PnV) has anticancer effects mainly o...

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Bibliographic Details
Main Authors: Natália Barreto, Marcus Caballero, Amanda Pires Bonfanti, Felipe Cezar Pinheiro de Mato, Jaqueline Munhoz, Thomaz A. A. da Rocha‐e‐Silva, Rafael Sutti, João Luiz Vitorino-Araujo, Liana Verinaud, Catarina Rapôso
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cancer Cell International
Subjects:
Phoneutria nigriventer
Cytoskeleton
Cell adhesion
Cell morphology
Metastasis
Cancer therapy
Online Access:https://doi.org/10.1186/s12935-020-01643-8

Internet

https://doi.org/10.1186/s12935-020-01643-8

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