Perineuronal nets affect memory and learning after synapse withdrawal
Abstract Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-11-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-02226-z |
| _version_ | 1811219359989760000 |
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| author | Jiri Ruzicka Marketa Dalecka Kristyna Safrankova Diego Peretti Pavla Jendelova Jessica C. F. Kwok James W. Fawcett |
| author_facet | Jiri Ruzicka Marketa Dalecka Kristyna Safrankova Diego Peretti Pavla Jendelova Jessica C. F. Kwok James W. Fawcett |
| author_sort | Jiri Ruzicka |
| collection | DOAJ |
| description | Abstract Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits. |
| first_indexed | 2024-04-12T07:25:58Z |
| format | Article |
| id | doaj.art-50eda852b9e34524b993f97aead30346 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-12T07:25:58Z |
| publishDate | 2022-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-50eda852b9e34524b993f97aead303462022-12-22T03:42:12ZengNature Publishing GroupTranslational Psychiatry2158-31882022-11-0112111310.1038/s41398-022-02226-zPerineuronal nets affect memory and learning after synapse withdrawalJiri Ruzicka0Marketa Dalecka1Kristyna Safrankova2Diego Peretti3Pavla Jendelova4Jessica C. F. Kwok5James W. Fawcett6Institute of Experimental Medicine, CASImaging Methods Core Facility, BIOCEV, CASInstitute of Experimental Medicine, CASUK Dementia Research Institute and Department of Clinical Neurosciences, University of CambridgeInstitute of Experimental Medicine, CASInstitute of Experimental Medicine, CASInstitute of Experimental Medicine, CASAbstract Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits.https://doi.org/10.1038/s41398-022-02226-z |
| spellingShingle | Jiri Ruzicka Marketa Dalecka Kristyna Safrankova Diego Peretti Pavla Jendelova Jessica C. F. Kwok James W. Fawcett Perineuronal nets affect memory and learning after synapse withdrawal Translational Psychiatry |
| title | Perineuronal nets affect memory and learning after synapse withdrawal |
| title_full | Perineuronal nets affect memory and learning after synapse withdrawal |
| title_fullStr | Perineuronal nets affect memory and learning after synapse withdrawal |
| title_full_unstemmed | Perineuronal nets affect memory and learning after synapse withdrawal |
| title_short | Perineuronal nets affect memory and learning after synapse withdrawal |
| title_sort | perineuronal nets affect memory and learning after synapse withdrawal |
| url | https://doi.org/10.1038/s41398-022-02226-z |
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