Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects

Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects

Abstract Cachexia syndrome develops in patients with diseases such as cancer and sepsis and is characterized by progressive muscle wasting. While iNOS is one of the main effectors of cachexia, its mechanism of action and whether it could be targeted for therapy remains unexplored. Here, we show that...

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Bibliographic Details
Main Authors: Jason Sadek, Derek T Hall, Bianca Colalillo, Amr Omer, Anne‐Marie K Tremblay, Virginie Sanguin‐Gendreau, William Muller, Sergio Di Marco, Marco Emilio Bianchi, Imed‐Eddine Gallouzi
Format: Article
Language:English
Published: Springer Nature 2021-06-01
Series:EMBO Molecular Medicine
Subjects:
cachexia
cancer
inflammation
iNOS
metabolism
Online Access:https://doi.org/10.15252/emmm.202013591

Internet

https://doi.org/10.15252/emmm.202013591

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