Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.

Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.

L-asparaginase (ASP) is a key element in the treatment of paediatric acute lymphoblastic leukaemia (ALL). However, hypersensitivity reactions (HSRs) to ASP are major challenges in paediatric patients. Our aim was to investigate genetic variants that may influence the risk to Escherichia coli-derived...

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Bibliographic Details
Main Authors: Nóra Kutszegi, Ágnes F Semsei, András Gézsi, Judit C Sági, Viktória Nagy, Katalin Csordás, Zsuzsanna Jakab, Orsolya Lautner-Csorba, Krisztina Míta Gábor, Gábor T Kovács, Dániel J Erdélyi, Csaba Szalai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4601692?pdf=render

Internet

http://europepmc.org/articles/PMC4601692?pdf=render

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