Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.

The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-...

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Bibliographic Details
Main Authors: Firhan A Malik, Anja Meissner, Illya Semenkov, Steven Molinski, Stan Pasyk, Saumel Ahmadi, Hai H Bui, Christine E Bear, Darcy Lidington, Steffen-Sebastian Bolz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4469317?pdf=render

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http://europepmc.org/articles/PMC4469317?pdf=render

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