Molecular Basis of Class B GPCR Selectivity for the Neuropeptides PACAP and VIP

Molecular Basis of Class B GPCR Selectivity for the Neuropeptides PACAP and VIP

The related neuropeptides PACAP and VIP, and their shared PAC1, VPAC1 and VPAC2 receptors, regulate a large array of physiological activities in the central and peripheral nervous systems. However, the lack of comparative and molecular mechanistic investigations hinder further understanding of their...

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Bibliographic Details
Main Authors: Chenyi Liao, Jacob M. Remington, Victor May, Jianing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
G protein-coupled receptor
membrane protein
signaling
molecular dynamics
conformational transition
ligand selectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.644644/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.644644/full

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