Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia. Vesicular glutamate transporter 2 (VGluT2) accumulates glutamate into synaptic vesicles and plays multiple roles in the central nervous...

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Bibliographic Details
Main Authors: Liqiong He, Wei Xu, Chengliang Zhang, Zhuofeng Ding, Qulian Guo, Wangyuan Zou, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
VGluT2
morphine tolerance
brain-derived neurotrophic factor
spinal cord
hyperalgesia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.861786/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.861786/full

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