Predicting bacterial promoter function and evolution from random sequences

Predicting bacterial promoter function and evolution from random sequences

Predicting function from sequence is a central problem of biology. Currently, this is possible only locally in a narrow mutational neighborhood around a wildtype sequence rather than globally from any sequence. Using random mutant libraries, we developed a biophysical model that accounts for multipl...

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Bibliographic Details
Main Authors: Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
gene regulation
RNA polymerase
genotype-phenotype map
adaptive evolution
promoter
Online Access:https://elifesciences.org/articles/64543

Internet

https://elifesciences.org/articles/64543

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