A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii

A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii

BackgroundNeurodegenerative diseases including AD is currently one of intractable problems globally due to the insufficiency of intervention strategies. Long-term infection of Toxoplasma gondii (T. gondii) can induce cognitive impairment in hosts, which is closely implicated in the pathogenesis of n...

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Bibliographic Details
Main Authors: Yan He, Daxiang Xu, Ziyi Yan, Yongshuai Wu, Yongsheng Zhang, Xiaokang Tian, Jinhang Zhu, Zhuanzhuan Liu, Wanpeng Cheng, Kuiyang Zheng, Xiaoying Yang, Yinghua Yu, Wei Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
Acod1/itaconate axis
neuroinflammation
cognition
synaptic plasticity
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1043572/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1043572/full

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