Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques.

Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques.

Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA vaccine formulated with a novel genetic adjuvant that stimulates immune responses in the blood and gut for the ability to improve therapy in rhe...

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Bibliographic Details
Main Authors: Deborah Heydenburg Fuller, Premeela Rajakumar, Jenny W Che, Amithi Narendran, Julia Nyaundi, Heather Michael, Eric J Yager, Cristy Stagnar, Brendon Wahlberg, Rachel Taber, Joel R Haynes, Fiona C Cook, Peter Ertl, John Tite, Angela M Amedee, Michael Murphey-Corb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3307760?pdf=render

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http://europepmc.org/articles/PMC3307760?pdf=render

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