Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

Abstract Background Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study ai...

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Bibliographic Details
Main Authors: Eri Watanabe, Akira Yokoi, Kosuke Yoshida, Mai Sugiyama, Masami Kitagawa, Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
choriocarcinoma
drug repositioning
ferroptosis
histone deacetylase inhibitors
vorinostat
Online Access:https://doi.org/10.1002/cam4.5243

Internet

https://doi.org/10.1002/cam4.5243

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