Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation

Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation

Chloride intracellular channel 4 (CLIC4) is a recently discovered driver of fibroblast activation in Scleroderma (SSc) and cancer-associated fibroblasts (CAF). CLIC4 expression and activity are regulated by TGF-β signalling through the SMAD3 transcription factor. In view of the aberrant activation o...

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Bibliographic Details
Main Authors: Christopher W. Wasson, Begoña Caballero-Ruiz, Justin Gillespie, Emma Derrett-Smith, Jamel Mankouri, Christopher P. Denton, Gianluca Canettieri, Natalia A. Riobo-Del Galdo, Francesco Del Galdo
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
fibrosis
Scleroderma
Ion channels
CLIC4
morphogens
Online Access:https://www.mdpi.com/2073-4409/11/3/530

Internet

https://www.mdpi.com/2073-4409/11/3/530

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