Grafting of Encapsulated Genetically Modified Cells Secreting GDNF into the Striatum of Parkinsonian Model Rats

In order to deliver glial cell line-derived neurotrophic factor (GDNF) into the brain, we have established a cell line that produces GDNF in a continuous fashion by genetic engineering. These cells were encapsulated and grafted into parkinsonian model rats that had received unilateral intrastriatal...

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Bibliographic Details
Main Authors: Isao Date M.D., Tetsuro Shingo, Hideyuki Yoshida, Kenjiro Fujiwara, Kazuki Kobayashi, Akira Takeuchi, Takashi Ohmoto
Format: Article
Language:English
Published: SAGE Publishing 2001-05-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000001783986486