A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism

A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism

Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic transmission and are crucial drug targets. Their gating mechanism is triggered by ligand binding in the extracellular domain that culminates in the opening of a hydrophobic gate in the transmembrane domain. This domain is made of fo...

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Bibliographic Details
Main Authors: Alessandro Crnjar, Susanne M. Mesoy, Sarah C. R. Lummis, Carla Molteni
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
pentameric ligand-gated ion channels
5-HT3 receptors
Cys-loop receptors
mutagenesis
molecular dynamics
M4 helix
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.644720/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.644720/full

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