The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells

The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells

To investigate the biological significance of Rho-associated coiled-coil-containing protein kinase (ROCK) 2 in the human trabecular meshwork (HTM), changes in both metabolic phenotype and gene expression patterns against a specific ROCK2 inhibitor KD025 were assessed in planar-cultured HTM cells. A...

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Bibliographic Details
Main Authors: Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Megumi Suzuki, Masato Furuhashi, Hiroshi Ohguro
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Biomedicines
Subjects:
XF real-time ATP rate assay
RNA sequencing
KD025
Rho-associated coiled-coil containing protein kinase (ROCK)
human trabecular meshwork (HTM)
Online Access:https://www.mdpi.com/2227-9059/12/6/1165

Internet

https://www.mdpi.com/2227-9059/12/6/1165

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