Generation of long tracts of disease-associated DNA repeats

The generation of long uninterrupted DNA repeats is important for the study of repeat instability associated with several human genetic diseases, including myotonic dystrophy type 1. However, obtaining defined lengths of long repeats in vitro has been problematic. Strand slippage and/or DNA secondar...

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Bibliographic Details
Main Authors: Seung-Hwan Kim, Lu Cai, Malgorzata J. Pytlos, Sharon F. Edwards, Richard R. Sinden
Format: Article
Language:English
Published: Taylor & Francis Group 2005-02-01
Series:BioTechniques
Online Access:https://www.future-science.com/doi/10.2144/05382RR01