Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells

Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells

3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic <i>N</i>-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free radicals that initiate the prooxida...

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Bibliographic Details
Main Authors: Aušra Nemeikaitė-Čėnienė, Per Haberkant, Dalius Kučiauskas, Frank Stein, Narimantas Čėnas
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
tirapazamine
reductive activation
oxidative stress
cytotoxicity
cell resistance
Online Access:https://www.mdpi.com/1422-0067/24/7/6863

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https://www.mdpi.com/1422-0067/24/7/6863

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