Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells

3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic <i>N</i>-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free radicals that initiate the prooxida...

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Bibliographic Details
Main Authors:	Aušra Nemeikaitė-Čėnienė, Per Haberkant, Dalius Kučiauskas, Frank Stein, Narimantas Čėnas
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	International Journal of Molecular Sciences
Subjects:	tirapazamine reductive activation oxidative stress cytotoxicity cell resistance
Online Access:	https://www.mdpi.com/1422-0067/24/7/6863

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