A cyclic adenosine monophosphate response element-binding protein inhibitor enhances the antibacterial activity of polymyxin B by inhibiting the ATP hydrolyzation activity of CrrB

A cyclic adenosine monophosphate response element-binding protein inhibitor enhances the antibacterial activity of polymyxin B by inhibiting the ATP hydrolyzation activity of CrrB

The emergence of polymyxin B (PB) resistant Gram-negative bacteria poses an important clinical and public health threat. Antibiotic adjuvants development is a complementary strategy that fills the gap in new antibiotics. Here, we described the discovery of the enhancement capacity of compound 666-15...

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Bibliographic Details
Main Authors: Wei Huang, Jinyong Zhang, Yuzhang He, Chunxia Hu, Shumin Cheng, Huan Zeng, Manling Zheng, Huijuan Yu, Xue Liu, Quanming Zou, Ruiqin Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
antibiotic adjuvant
Klebsiella pneumoniae
polymyxin B resistant
lipid A
lipopolysaccharide
two-component system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.949869/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.949869/full

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