Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis

Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities. Mutations in the 3′5′cyclic AMP (cAMP)-dependent protein kinase (PKA) type I regulatory subunit isoform α (RIα) and phosphodiesterase (PD...

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Bibliographic Details
Main Authors: Varun Venkatakrishnan, Abhijeet Ghode, Nikhil K. Tulsian, Ganesh S. Anand
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
acrodysostosis
protein kinase A
RIα
phosphodiesterase
signal termination
allostery
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1202268/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1202268/full

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