Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis
Osteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis is usually present upon initial diagnosis, and metastasis is the primary factor affecting the poor prognosis of patients with OS. Current research shows that the ability to regulate the cellular microenv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1350187/full |
| _version_ | 1797347881280077824 |
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| author | Jianghu Zhou Fengjun Lan Miao Liu Fengyan Wang Xu Ning Hua Yang Hong Sun |
| author_facet | Jianghu Zhou Fengjun Lan Miao Liu Fengyan Wang Xu Ning Hua Yang Hong Sun |
| author_sort | Jianghu Zhou |
| collection | DOAJ |
| description | Osteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis is usually present upon initial diagnosis, and metastasis is the primary factor affecting the poor prognosis of patients with OS. Current research shows that the ability to regulate the cellular microenvironment is essential for preventing the distant metastasis of OS, and anoxic microenvironments are important features of solid tumors. During hypoxia, hypoxia-inducible factor-1α (HIF-1α) expression levels and stability increase. Increased HIF-1α promotes tumor vascular remodeling, epithelial-mesenchymal transformation (EMT), and OS cells invasiveness; this leads to distant metastasis of OS cells. HIF-1α plays an essential role in the mechanisms of OS metastasis. In order to develop precise prognostic indicators and potential therapeutic targets for OS treatment, this review examines the molecular mechanisms of HIF-1α in the distant metastasis of OS cells; the signal transduction pathways mediated by HIF-1α are also discussed. |
| first_indexed | 2024-03-08T11:55:19Z |
| format | Article |
| id | doaj.art-511c00d47f2d4c58bbc635f769333c74 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T11:55:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-511c00d47f2d4c58bbc635f769333c742024-01-24T04:17:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011510.3389/fphar.2024.13501871350187Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasisJianghu Zhou0Fengjun Lan1Miao Liu2Fengyan Wang3Xu Ning4Hua Yang5Hong Sun6Department of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopaedics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaOsteosarcoma (OS) is a malignant tumor originating from mesenchymal tissue. Pulmonary metastasis is usually present upon initial diagnosis, and metastasis is the primary factor affecting the poor prognosis of patients with OS. Current research shows that the ability to regulate the cellular microenvironment is essential for preventing the distant metastasis of OS, and anoxic microenvironments are important features of solid tumors. During hypoxia, hypoxia-inducible factor-1α (HIF-1α) expression levels and stability increase. Increased HIF-1α promotes tumor vascular remodeling, epithelial-mesenchymal transformation (EMT), and OS cells invasiveness; this leads to distant metastasis of OS cells. HIF-1α plays an essential role in the mechanisms of OS metastasis. In order to develop precise prognostic indicators and potential therapeutic targets for OS treatment, this review examines the molecular mechanisms of HIF-1α in the distant metastasis of OS cells; the signal transduction pathways mediated by HIF-1α are also discussed.https://www.frontiersin.org/articles/10.3389/fphar.2024.1350187/fullosteosarcomaHIF-1ɑmetastasiscellular microenvironmentsignaling pathwaystherapy |
| spellingShingle | Jianghu Zhou Fengjun Lan Miao Liu Fengyan Wang Xu Ning Hua Yang Hong Sun Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis Frontiers in Pharmacology osteosarcoma HIF-1ɑ metastasis cellular microenvironment signaling pathways therapy |
| title | Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| title_full | Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| title_fullStr | Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| title_full_unstemmed | Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| title_short | Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| title_sort | hypoxia inducible factor 1ɑ as a potential therapeutic target for osteosarcoma metastasis |
| topic | osteosarcoma HIF-1ɑ metastasis cellular microenvironment signaling pathways therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1350187/full |
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