Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of the extracellular matrix (ECM), vascular inflammation, and oxidative stress are hallmarks of AAA pathogenesis and co...

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Bibliographic Details
Main Authors: Rijan Gurung, Andrew Mark Choong, Chin Cheng Woo, Roger Foo, Vitaly Sorokin
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
abdominal aortic aneurysm
vascular smooth muscle cells
single nucleotide polymorphism
epigenetics
extracellular matrix
phenotypic switching
Online Access:https://www.mdpi.com/1422-0067/21/17/6334

Internet

https://www.mdpi.com/1422-0067/21/17/6334

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