Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity

The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer’s disease. Similarly, abnormal tau aggregate accumulation in neurons is a hallmark of various neurod...

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Bibliographic Details
Main Authors: Taha F. S. Ali, Halil I. Ciftci, Mohamed O. Radwan, Eslam Roshdy, Ahmed M. Shawky, Mohammed A. S. Abourehab, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
azaindolin-2-one
GSK3β
Tau
protein aggregation
neurofibrillary tangles
neuroprotective
Online Access:https://www.mdpi.com/1424-8247/15/4/426

Internet

https://www.mdpi.com/1424-8247/15/4/426

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