Augmented thrombin formation is related to circulating levels of extracellular vesicles exposing tissue factor and citrullinated histone-3 in anti-neutrophil cytoplasmic antibody-associated vasculitides

Augmented thrombin formation is related to circulating levels of extracellular vesicles exposing tissue factor and citrullinated histone-3 in anti-neutrophil cytoplasmic antibody-associated vasculitides

ObjectivesTo study circulating myeloperoxidase (MPO)-positive extracellular vesicles (MPO+EVs) exposing citrullinated histone-3 (H3Cit), tissue factor (TF), and plasminogen (Plg) in association to thrombin generation in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (A...

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Bibliographic Details
Main Authors: Asta Dogg Jonasdottir, Milena Manojlovic, Jelena Vojinovic, Annica Nordin, Annette Bruchfeld, Iva Gunnarsson, Fariborz Mobarrez, Aleksandra Antovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Medicine
Subjects:
anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
extracellular vesicles
thrombin generation
NETs
tissue factor
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1240325/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1240325/full

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