Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson’s disease and other neurological disorders

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson’s disease and other neurological disorders

Mutations in ATP13A2 lead to Kufor-Rakeb syndrome, a parkinsonism with dementia. ATP13A2 belongs to the P-type transport ATPases, a large family of primary active transporters that exert vital cellular functions. However, the cellular function and transported substrate of ATP13A2 remain unknown. To...

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Bibliographic Details
Main Authors: Sarah evan Veen, Danny Mollerup Sorensen, Tine eHolemans, Henrik Waldal Holen, Michael G. Palmgren, Peter eVangheluwe
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
alpha-Synuclein
Autophagy
Heavy Metal Poisoning, Nervous System
Lysosomes
Manganese
Mitochondria
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00048/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00048/full

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