Proinflammatory Pathways Are Activated in the Human Q344X Rhodopsin Knock-In Mouse Model of Retinitis Pigmentosa

Proinflammatory Pathways Are Activated in the Human Q344X Rhodopsin Knock-In Mouse Model of Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a hereditary disease of the retina that results in complete blindness. Currently, there are very few treatments for the disease and those that exist work only for the recessively inherited forms. To better understand the pathogenesis of RP, multiple mouse models have bee...

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Bibliographic Details
Main Authors: T.J. Hollingsworth, Meredith G. Hubbard, Hailey J. Levi, William White, Xiangdi Wang, Raven Simpson, Monica M. Jablonski, Alecia K. Gross
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
retinal degeneration
retinitis pigmentosa
rhodopsin
inflammation
microglia
TNFα, NF-κB
Online Access:https://www.mdpi.com/2218-273X/11/8/1163

Internet

https://www.mdpi.com/2218-273X/11/8/1163

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