Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma

Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma

Abstract Multiple myeloma (MM) and its precursors monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) are 2–3 times more common in African Americans (AA) than European Americans (EA). Although epigenetic changes are well recognized in the context of myeloma cell bi...

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Bibliographic Details
Main Authors: Brian C.-H. Chiu, Zhou Zhang, Benjamin A. Derman, Jason Karpus, Liangzhi Luo, Sheng Zhang, Spencer S. Langerman, Madina Sukhanova, Parveen Bhatti, Andrzej Jakubowiak, Chuan He, Wei Zhang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Hematology & Oncology
Subjects:
Multiple myeloma
5-hydroxymethylcytosine
Racial disparity
Epigenetic modification
Online Access:https://doi.org/10.1186/s13045-022-01327-y

Internet

https://doi.org/10.1186/s13045-022-01327-y

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