Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

Abstract Background Cardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase activity is enhanced in hyperglycemic conditions, leading to altered cardiac energy metabolism and deterioration of cardiac function with adverse...

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Bibliographic Details
Main Authors: Keshav Gopal, Qutuba G. Karwi, Seyed Amirhossein Tabatabaei Dakhili, Cory S. Wagg, Liyan Zhang, Qiuyu Sun, Christina T. Saed, Sai Panidarapu, Riccardo Perfetti, Ravichandran Ramasamy, John R. Ussher, Gary D. Lopaschuk
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cardiovascular Diabetology
Subjects:
AT-001
Aldose reductase
Fatty acid oxidation
Diabetic cardiomyopathy
Diastolic dysfunction
Online Access:https://doi.org/10.1186/s12933-023-01811-w

Internet

https://doi.org/10.1186/s12933-023-01811-w

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