Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

Stimulator of interferon genes (STING) agonists have shown potent anti-tumor efficacy in various mouse tumor models and have the potential to overcome resistance to immune checkpoint inhibitors (ICI) by linking the innate and acquired immune systems. First-generation STING agonists are administered...

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Bibliographic Details
Main Authors: Andreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, Sarah K. Stevens, Antitsa Stoycheva, Vivek K. Rajwanshi, Caroline Williams, Jerome Deval, Sucheta Mukherjee, Qingling Zhang, Sushmita Chanda, David B. Smith, Lawrence M. Blatt, Julian A. Symons, Francois Gonzalvez, Leonid Beigelman
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
immuno-oncology
STING agonist
immune checkpoint inhibitor
syngeneic mouse model
Online Access:https://www.mdpi.com/1422-0067/24/22/16274

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https://www.mdpi.com/1422-0067/24/22/16274

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