Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure

Computational Saturation Mutagenesis to Investigate the Effects of Neurexin-1 Mutations on AlphaFold Structure

Neurexin-1 (NRXN1) is a membrane protein essential in synapse formation and cell signaling as a cell-adhesion molecule and cell-surface receptor. NRXN1 and its binding partner neuroligin have been associated with deficits in cognition. Recent genetics research has linked NRXN1 missense mutations to...

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Bibliographic Details
Main Authors: Raina Rhoades, Brianna Henry, Dominique Prichett, Yayin Fang, Shaolei Teng
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Genes
Subjects:
neurexin-1
AlphaFold
missense mutation
protein stability
computational saturation mutagenesis
Online Access:https://www.mdpi.com/2073-4425/13/5/789

Internet

https://www.mdpi.com/2073-4425/13/5/789

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