Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Given the skyrocketing costs to develop new drugs, repositioning of approved drugs, such as histone deacetylase (HDAC) inhibitors, may be a promising strategy to develop novel therapies. However, a gap exists in the understanding and advancement of these agents to meaningful translation for which ne...

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Bibliographic Details
Main Authors: Haloom Rafehi, Antony Kaspi, Mark Ziemann, Jun Okabe, Tom C. Karagiannis, Assam El-Osta
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:Epigenetics
Subjects:
epigenomics
hdac inhibitors
meta-analysis
saha
histone acetylation
diabetes
endothelial dysfunction
network analysis
pathway analysis
computation biology
Online Access:http://dx.doi.org/10.1080/15592294.2017.1371892

Internet

http://dx.doi.org/10.1080/15592294.2017.1371892

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