In Silico and In Vitro Tailoring of a Chitosan Nanoformulation of a Human Metabolic Enzyme

In Silico and In Vitro Tailoring of a Chitosan Nanoformulation of a Human Metabolic Enzyme

Enzyme nanoencapsulation holds an enormous potential to develop new therapeutic approaches to a large set of human pathologies including cancer, infectious diseases and inherited metabolic disorders. However, enzyme formulation has been limited by the need to maintain the catalytic function, which i...

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Bibliographic Details
Main Authors: Paulo R. Lino, João Leandro, Mariana Amaro, Lídia M. D. Gonçalves, Paula Leandro, António J. Almeida
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
chitosan
molecular modelling
enzyme therapeutics
self-assembly
nanoencapsulation
human phenylalanine hydroxylase
Online Access:https://www.mdpi.com/1999-4923/13/3/329

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https://www.mdpi.com/1999-4923/13/3/329

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