Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

The present work aims to synthesize four series of phenothiazine incorporation Mannich bases. Therefore, 10-methyl-10H-phenothiazine-3-sulfonamide (4) which was subjected to react with some secondary amines and formaldehyde to give the Mannich bases 5a-f, and 6–13. Compound 13 was then subjected to...

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Bibliographic Details
Main Authors: Ahmed M. Abdula, Ahmad Fawzi Qarah, Kahdr Alatawi, Jihan Qurban, Matokah M. Abualnaja, Hanadi A. Katuah, Nashwa M. El-Metwaly
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
Phenothiazine
N-Mannich bases
Molecular docking
Antimicrobial agent
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024046048

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024046048

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