Isolevuglandins Promote Mitochondrial Dysfunction and Electrophysiologic Abnormalities in Atrial Cardiomyocytes

Isolevuglandins Promote Mitochondrial Dysfunction and Electrophysiologic Abnormalities in Atrial Cardiomyocytes

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, yet the cellular and molecular mechanisms underlying the AF substrate remain unclear. Isolevuglandins (IsoLGs) are highly reactive lipid dicarbonyl products that mediate oxidative stress-related injury. In murine hypertension,...

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Bibliographic Details
Main Authors: Tuerdi Subati, Zhenjiang Yang, Matthew B. Murphy, Joshua M. Stark, David Z. Trykall, Sean S. Davies, Joey V. Barnett, Katherine T. Murray
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
Isolevuglandins
oxidative stress
lipid dicarbonyl
atrial HL-1 cells
mitochondria
electrophysiology
Online Access:https://www.mdpi.com/2073-4409/13/6/483

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https://www.mdpi.com/2073-4409/13/6/483

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