Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma

Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma

Abstract Background Mitochondria play essential roles in tumorigenesis; however, little is known about the contribution of mitochondrial DNA (mtDNA) to esophageal squamous cell carcinoma (ESCC). Whole-genome sequencing (WGS) is by far the most efficient technology to fully characterize the molecular...

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Bibliographic Details
Main Authors: Xuehan Zhuang, Rui Ye, Yong Zhou, Matthew Yibo Cheng, Heyang Cui, Longlong Wang, Shuangping Zhang, Shubin Wang, Yongping Cui, Weimin Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Genome Medicine
Subjects:
Mitochondrial DNA
Esophageal squamous cell carcinoma
Non-ref NUMTs
mtDNA copy number
mtDNA variants
Online Access:https://doi.org/10.1186/s13073-024-01319-2

Internet

https://doi.org/10.1186/s13073-024-01319-2

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