Oral Administration of a Shigella 2aT32-Based Vaccine Expressing UreB-HspA Fusion Antigen With and Without Parenteral rUreB-HspA Boost Confers Protection Against Helicobacter pylori in Mice Model

Oral Administration of a Shigella 2aT32-Based Vaccine Expressing UreB-HspA Fusion Antigen With and Without Parenteral rUreB-HspA Boost Confers Protection Against Helicobacter pylori in Mice Model

Helicobacter pylori (H. pylori) is a gram-negative pathogen classified as a class I carcinogen. The H. pylori urease B subunit (UreB) and heat shock protein A (HspA) are two important vaccine candidate antigens. In this study, we evaluated the immunogenicity and immunoprotective effect of the attenu...

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Bibliographic Details
Main Authors: Xin Zhang, Shuli Sang, Qing Guan, Haoxia Tao, Yanchun Wang, Chunjie Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
Helicobacter pylori
vaccine
UreB
HspA
immune protection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.894206/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.894206/full

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