YO2 Induces Melanoma Cell Apoptosis through p53-Mediated LRP1 Downregulation

The multifunctional endocytic receptor low-density lipoprotein receptor-related protein 1 (LRP1) has been implicated in melanoma growth. However, the mechanism of LRP1 expression in melanoma cells remains only partially understood. In most melanomas, the TP53 tumor suppressor is retained as a non-mu...

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Bibliographic Details
Main Authors: Yousef Salama, Satoshi Takahashi, Yuko Tsuda, Yoshio Okada, Koichi Hattori, Beate Heissig
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/15/1/288