Mitochondrial Transplantation Therapy Ameliorates Muscular Dystrophy in <i>mdx</i> Mouse Model

Mitochondrial Transplantation Therapy Ameliorates Muscular Dystrophy in <i>mdx</i> Mouse Model

Duchenne muscular dystrophy is caused by loss of the dystrophin protein. This pathology is accompanied by mitochondrial dysfunction contributing to muscle fiber instability. It is known that mitochondria-targeted in vivo therapy mitigates pathology and improves the quality of life of model animals....

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Bibliographic Details
Main Authors: Mikhail V. Dubinin, Irina B. Mikheeva, Anastasia E. Stepanova, Anastasia D. Igoshkina, Alena A. Cherepanova, Alena A. Semenova, Vyacheslav A. Sharapov, Igor I. Kireev, Konstantin N. Belosludtsev
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomolecules
Subjects:
Duchenne muscular dystrophy
skeletal muscle
mitochondrial dysfunction
mitochondrial transplantation
lipid peroxidation
muscle force
Online Access:https://www.mdpi.com/2218-273X/14/3/316

Internet

https://www.mdpi.com/2218-273X/14/3/316

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