Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction

Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction

The preclinical identification of drug-induced cardiotoxicity and its translation into human risk are still major challenges in pharmaceutical drug discovery. The ICH S7B Guideline and Q&A on Clinical and Nonclinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential prom...

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Bibliographic Details
Main Authors: Cristian Trovato, Marcel Mohr, Friedemann Schmidt, Elisa Passini, Blanca Rodriguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Toxicology
Subjects:
in silico trials
cardiac electrophysiology
computer modelling
drug safety
purkinje fibre
cardiac arrythmia
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.992650/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2022.992650/full

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