Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region

Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region

Novel amino-substituted pyridoquinazolinone derivatives have been designed and synthesized as potential c-MYC G-quadruplex (G4) ligands, employing an efficient methodology. All the new compounds exhibited moderate to good antiproliferative activity against the human osteosarcoma U2OS cell line. NMR...

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Bibliographic Details
Main Authors: Salvatore Princiotto, Maria Karelou, Rachel Ioannidi, Giovanni Luca Beretta, Nadia Zaffaroni, Roberto Artali, Ioannis K. Kostakis, Stefania Mazzini, Sabrina Dallavalle
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
c-MYC
G-quadruplex
BMH21
antiproliferative activity
NMR spectroscopy
molecular modeling
Online Access:https://www.mdpi.com/1422-0067/24/18/14346

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https://www.mdpi.com/1422-0067/24/18/14346

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