Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model

Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model

Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. Since mutations in GDAP1 cause Charcot–Marie–Tooth, an inherited motor and senso...

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Bibliographic Details
Main Authors: Azahara Civera-Tregón, Laura Domínguez, Paula Martínez-Valero, Clàudia Serrano, Alex Vallmitjana, Raúl Benítez, Janet Hoenicka, Jorgina Satrústegui, Francesc Palau
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neurobiology of Disease
Subjects:
Axon
Bioenergetics
Calcium
Charcot-Marie-Tooth disease
Embryonic motor neurons
GDAP1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000498

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http://www.sciencedirect.com/science/article/pii/S0969996121000498

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