Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury

Abstract Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family. Although TLR5 has previously been implicated in different CNS disorders incl...

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Bibliographic Details
Main Authors: Masataka Ifuku, Lukas Hinkelmann, Leonard D. Kuhrt, Ibrahim E. Efe, Victor Kumbol, Alice Buonfiglioli, Christina Krüger, Philipp Jordan, Marcus Fulde, Mami Noda, Helmut Kettenmann, Seija Lehnardt
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Acta Neuropathologica Communications
Subjects:
Toll-like receptor 5
Microglia
PI3K/Akt/mTORC1 signaling
Cytokines
Phagocytosis
Chemotaxis
Online Access:http://link.springer.com/article/10.1186/s40478-020-01031-3

Internet

http://link.springer.com/article/10.1186/s40478-020-01031-3

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