Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

A variety of 2-amino-3-arylpropan-1-ols, anti-2-amino-3-aryl-3-methoxypropan-1-ols and anti-2-amino-1-arylpropan-1,3-diols were prepared selectively through elaboration of trans-4-aryl-3-chloro-β-lactams. In addition, a number of 2-(azidomethyl)aziridines was converted into novel 2-[(1,2,3-triazol-1...

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Bibliographic Details
Main Authors: Matthias D’hooghe, Stéphanie Vandekerckhove, Karen Mollet, Karel Vervisch, Stijn Dekeukeleire, Liesbeth Lehoucq, Carmen Lategan, Peter J. Smith, Kelly Chibale, Norbert De Kimpe
Format: Article
Language:English
Published: Beilstein-Institut 2011-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aminopropanes
antimalarial activity
aziridines
β-lactams
ring opening
Online Access:https://doi.org/10.3762/bjoc.7.205

Internet

https://doi.org/10.3762/bjoc.7.205

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