Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1

Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1

Abstract Background Understanding the mechanism behind immune cell plasticity in cancer metastasis is crucial for identifying key regulators. Previously we found that mitotic factors regulate epithelial-mesenchymal transition, but how these factors convert to metastatic players in the tumor microenv...

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Bibliographic Details
Main Authors: Rong Xu, Young-Joo Lee, Chang-Hyeon Kim, Ga-Hong Min, Yeo-Bin Kim, Jung-Won Park, Dae-Hoon Kim, Jung-Hyun Kim, Hyungshin Yim
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
FoxM1
Phosphorylation
PLK1
Invasiveness
Tumor-associated macrophages
Online Access:https://doi.org/10.1186/s13046-023-02872-1

Internet

https://doi.org/10.1186/s13046-023-02872-1

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