Comparative Efficiency of Gene-Activated Matrices Based on Chitosan Hydrogel and PRP Impregnated with <i>BMP2</i> Polyplexes for Bone Regeneration

Comparative Efficiency of Gene-Activated Matrices Based on Chitosan Hydrogel and PRP Impregnated with <i>BMP2</i> Polyplexes for Bone Regeneration

Gene therapy is one of the most promising approaches in regenerative medicine. Gene-activated matrices provide stable gene expression and the production of osteogenic proteins in situ to stimulate osteogenesis and bone repair. In this study, we developed new gene-activated matrices based on polylact...

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Bibliographic Details
Main Authors: Irina Alekseevna Nedorubova, Tatiana Borisovna Bukharova, Viktoria Olegovna Mokrousova, Maria Aleksandrovna Khvorostina, Andrey Vyacheslavovich Vasilyev, Andrey Anatolevich Nedorubov, Timofei Evgenevich Grigoriev, Yuriy Dmitrievich Zagoskin, Sergei Nicolaevich Chvalun, Sergey Ivanovich Kutsev, Dmitry Vadimovich Goldshtein
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
gene-activated matrices
plasmid DNA
polylactide granules
chitosan
platelet rich plasma
bone regeneration
Online Access:https://www.mdpi.com/1422-0067/23/23/14720

Internet

https://www.mdpi.com/1422-0067/23/23/14720

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