PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

Paired related homeobox 1 (PRRX1) is an inducer of epithelial‐to‐mesenchymal transition (EMT) in different types of cancer cells. We detected low PRRX1 expression in nevus but increased levels in primary human melanoma and cell lines carrying the BRAFV600E mutation. High expression of PRRX1 correlat...

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Bibliographic Details
Main Authors: Josep R. Ferreres, Antònia Vinyals, Rafael Campos‐Martin, Roderic Espín, Sebastian Podlipnik, Raquel Ramos, Esther Bertran, Cristina Carrera, Joaquim Marcoval, Josep Malvehy, Isabel Fabregat, Susana Puig, Àngels Fabra
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Molecular Oncology
Subjects:
BRAF
EMT‐MET
melanoma
phenotypic plasticity
prognostic of survival
PRRX1
Online Access:https://doi.org/10.1002/1878-0261.13688

Internet

https://doi.org/10.1002/1878-0261.13688

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