Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets

Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets

Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The amplification of 1q21 is one of the most common cytogenetic abnormalities occurring in around 40% of <i>de novo</i> patients and 70% of relapsed/refractory MM. Patients...

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Bibliographic Details
Main Authors: Jessica Burroughs Garcìa, Rosa Alba Eufemiese, Paola Storti, Gabriella Sammarelli, Luisa Craviotto, Giannalisa Todaro, Denise Toscani, Valentina Marchica, Nicola Giuliani
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
multiple myeloma
1q21
chromosome aberrations
amplification
<i>IL6R</i>
<i>ILF2</i>
Online Access:https://www.mdpi.com/2073-4409/10/6/1360

Internet

https://www.mdpi.com/2073-4409/10/6/1360

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