p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer

p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer

Abstract Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatment of a wide range of cancers, including HNSCC. Its mode of action relies on its...

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Bibliographic Details
Main Authors: Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C. Sandulache, Eric H-B. Huang, Timothy F. Burns, Umamaheswar Duvvuri
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
p90RSK
TMEM16A
Cisplatin
Resistance
BI-1870
Online Access:https://doi.org/10.1186/s12885-024-11892-9

Internet

https://doi.org/10.1186/s12885-024-11892-9

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